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Henry J. Kaplan, M.D."I would like to see us recognized, nationally and internationally, as a center of excellence in both clinical care and scientific research. Our goal is to become one of the foremost medical research centers for ophthalmology in the country... Louisville is one of the few major cities in the United States where there is no overabundance of specialists in Ophthalmology. The opportunity for talented people to succeed here is excellent." To Schedule an Appointment with Dr. Kaplan, Call 502-852-5466 |
The success of any scientific or medical establishment is measured by its ability to enhance the pace of research, expand the boundaries of investigation, inspire innovation, encourage support, attract talent, and set a standard for quality that will raise the bar for the foreseeable future. In each of these aspects, Dr. Henry J. Kaplan has brought a new level of excitement and excellence through his leadership of the Kentucky Lions Eye Center and the Department of Ophthalmology and Visual Science at the University of Louisville.
As well as being a uniquely skilled medical practitioner, Dr. Kaplan is internationally acknowledged as a major force in ophthalmological research, in a field with relatively few clinician/scientists. Although he began his career as a cardiovascular surgeon, he went on to help discover a new field of ocular science known as Anterior Chamber Associated Immune Deviation. From that point on, his hunger for scientific research could not be quenched.
Dr. Kaplan, in collaboration with a diverse team of researchers, focuses on two main fields of study: retinal/macular degeneration and uveitis. He has helped establish the Kentucky Lions Eye Center as the only facility in the US, where both clinical trials and research applications of photoreceptor tissue transplantation occur side by side. Additional investigations by Dr. Kaplan and his team explore the intricacies of stem cell research, angiogenesis, autoimmune uveitis, and the retinal prosthesis, along with the Speed School of Engineering, Harvard University, and MIT. Much of this cutting edge translational research offers the bridge between basic scientific research with direct clinical application, creating an exceptional environment for the fostering of fresh ideas in ophthalmology.
Current Position
Evans Professor of Ophthalmology Chairman, Department of Ophthalmology & Visual Sciences Director, Kentucky Lions Eye Center On Staff since 2000
Specialties
Uveitis
Retinitis
Board Certification
American Board of Ophthalmology
National Board of Medical
Medical License
Kentucky, Illinois, Missouri, Georgia, Wisconsin, Iowa, California, Texas, New York
Contact Information
hank.kaplan@louisville.edu
University of Louisville
Dept. Of Ophthalmology & Visual Science
301 E. Muhammad Ali Blvd.
Louisville, KY 40202
502-852-5466
FAX 502-852-4595
Education
Columbia College of Columbia University, New York, NY, A.B. 1964
Cornell Medical School of Cornell University, NY, NY, M.D. 1968
Lakeside Hospital, The University Hospitals of Cleveland, Case-Western Reserve University, Cleveland, Ohio Internship in Medicine, 1968-1969
Bellevue Hospital, New York University Medical Center, New York, NY, Surgical Residency; 1969-1970
Department of Cell Biology, University of Texas (Southwestern) Medical School, Dallas, TX, NIH Research Fellowship in Immunology; 1972-1974
University of Iowa Hospitals and Clinics, Iowa City, Iowa, Ophthalmology Residency, 1975- 1978
Medical College of Wisconsin, Milwaukee, Wisconsin, Retina-Vitreous Fellowship, 1978-1979
Professional Societies and Affiliations
Association for Research in Vision and Ophthalmology, Fellow -American Academy of Ophthalmology, American Medical Association, American Association of Immunologists, Macula Society, American Uveitis Society, Vitreous Society, Fellow - The American College of Surgeons, The Retina Society, Louisville Society of Ophthalmology, Jefferson County Medical Society, Kentucky Ophthalmologic Society, and the Kentucky Medical Association.
Current Research Grants
Principal Investigator
7 RO1 EY13094-03
Henry J. Kaplan, P.I.
Project Period: 09/30/99-9/29/05 NIH/NEI
Title: In vivo imaging in autoimmune uveitis Study of cell trafficking, and adhesion molecule/cytokine receptor expression in an animal model of uveitis, using radioligands and a micro-PET scanner.
1R24 EY01 5636-01
Henry J. Kaplan, P. I
Project Period: 04/01/04-03/31/09 NIH/NEI
Title: Vision Research Infrastructure Development
Co-investigator
1 RO1 EY13335001A1
Nalini S. Bora, P.I.
Project Period: 8/1/01-7/31/05 NIH/NEI
Henry J. Kaplan, Co-investigator
Title: Complement system and the eye Study of the role of complement in experimental animal model of uveitis.
SBIR
John Naber, P.I.
Project Period: 4/1/03-3/31/05 NIH/NEI
Henry J. Kaplan, Co-investigator
Title: A real time monitoring system for IOP in glaucoma A collaborative effort between the Bioengineering Division of the Speed School of Engineering and the Department of Ophthalmology & Visual Sciences at the University of Louisville to develop and commercialize an intraocular glaucoma sensor that will continuously record IOP in a 24 hour cycle.
R01 EY014623
Puran S. Bora, P.I.
Project Period: 4/01/03-3/31/07 NIH/NEI
Henry J. Kaplan, Co-investigator
Title: Complement system and choroidal neovascularization This proposal explores the role of complement in the etiology of choroidal neovascularization in a laser-induced rodent model. It is an outgrowth of our novel observations that C3 and C5 are required for choroidal angiogenesis.
Select Publications
Berger, A.S., Tezel, T., Del Priore, L., Kaplan, H.J.: Photoreceptor Transplantation in Retinitis Pigmentosa: Short-term Follow-up. Ophthalmology, 110(2): 383-391, 2003.
Sohn, J.-H., Bora, P.S., Suk, H.-J., Molina, H., Kaplan, H.J., Bora, N.S.: Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Nat. Med. 9(2):206-212, 2003.
Bora, P.S., Hu, Z, Tezel, T.H., Sohn, J.H., Kang, S.G., Cruz, J.M., Bora, N.S.: Immunotherapy for choroidal neovascularization in a laser_induced mouse model simulating exudative (wet) macular degeneration. Proc. Natl. Acad. Sci. USA 100(5):2679-2684), 2003.
Tezel TH, DelPriore L, Kaplan HJ: Re-engineering of aged Bruch's membrane to enhance retinal pigment epithelium repopulation. Invest. Ophthalmol. Vis. Sci 45(9):3337-3348, 2004.
Tezel TH, Bora NS, Kaplan HJ: Pathogenesis of age-related macular degeneration. Trends in Mol. Med. 10(9):417-420, 2004.
Bora, P.S., Sohn, J.H., Cruz, J.M., Nishihori, H., Wang, Y., Kaliappan, S., Kaplan, H.J., Bora, N.S.: Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization. J Immunol. 174(1):491-497, 2005.
Yamauchi, Y., Franco, L.M., Jackson, D.J., Naber, J.F., Ziv, R.O., Rizzo III, J.F., Kaplan, H.J., Enzmann, V.: Comparison of electrically evoked cortical potential thresholds generated with subretinal or suprachoroidal placement of a microelectrode array in the rabbit. J. Neural Eng. 2:548-556, 2005.