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Hui Shao, M.D., Ph.D."Fighting diseases requires a better combination of medical doctors and researchers. We need to build both. We need better treatments for the patients, and these will come from researchers. We need medical doctors to discover the mechanisms behind the illnesses and pharmacologists to develop better medicines. Especially for uveitis." |
Hui Shao was in her final year as a medical student in China when she realized that many of the senior doctors didn't really understand the science behind their practice. They knew what to do, but they were not always sure exactly what underlying mechanism of the diseases they were treating. That wasn't good enough for the young scientist. So right after graduating from medical school, she enrolled in an MS program, figuring that once she knew the research she could help her fellow clinicians and serve her patients better. Over time, her fascination with research increased, and she went on to receive a Ph.D. in Immunology in Germany.
Today, Dr. Shao applies her medical and research skills to the study of the eye. Her work with animal models explores autoreactive T-cell activation, in an attempt to develop better treatments for uveitis and ocular autoimmune diseases.
Current Position
Associate Professor, Department of Ophthalmology & Visual Sciences
Associate Professor, Department of Microbiology & Immunology On Staff since
2001
Research Specialties
Uveitis Immunology
Contact Information
h0shao01@louisville.edu
University of Louisville
Dept. Of Ophthalmology & Visual Science
301 E. Muhammad Ali Blvd.
Louisville, KY 40202
(502) 852-1329
FAX - (502) 852-4655
Current Grants
2000-2011 : "The role of costimulatory molecules in uveitis "; Principal Investigator. Agency: NIH/NEI, Type: 2 R01 EY012974-05A2 ; Direct cost current year (12/01/2006 - 11/30/2007 ): $250,000.
2004-2008: "Ocular Immune Regulation by RPE", Principal Investigator. Agency NIH/NEI, Type: 1R01 EY14599-01A2, Direct cost current year (8/1/2006-7/30/2007): $175,000.
2006-2007: Research to Prevent Blindness (RPB) Career Development Award. $60,000.
Select Publications
Zhang P, Sun D, Ke Y, Kaplan HJ, Shao H: The net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells. J Immunol. 2007 Jan 1;178(1):474-9
Han G, Shao H, Peng Y, Zhang P, Ke Y, Kaplan HJ, Sun D: Suppressor role of rat CD8(+)CD45RC(low) T cells in experimental autoimmune uveitis (EAU). J Neuroimmunol. 2006 Dec 27; [Epub ahead of print]
Liao T, Y Ke, W-H Shao, B Haribabu, HJ. Kaplan, D Sun , H. Shao. Blockade of the interaction of leukotriene B4 with its receptor prevents development of autoimmune uveitis , Invest Ophthalmol Vis Sci. 47(4):1543-9 . 2006
Yong P, H. Shao, Y. Ke, P Zhang, J. Xiang, HJ Kaplan, D. Sun. In vitro activation of CD8 interphotoreceptor retinoid-binding protein (IRBP)-specific T cells requires not only antigenic stimulation, but also exogenous growth factors. J Immunol 176(8):5006-14. 2006
Shao H, Liao T, Ke Y, Shi H, Kaplan HJ, Sun D. Severe chronic experimental autoimmune uveitis (EAU) of the C57BL/6 mouse induced by adoptive transfer of IRBP1-20-specific T cells. Exp Eye Res. 82(2): 323-31. 2006
Shao, H., Y . Peng, T . Liao, HJ. Kaplan, D . Sun . CD4 + and CD8 + autoreactive T cells specific for interphotoreceptor retinoid-binding protein (IRBP) share to recognize a same antigenic epitope . J Immunol , 175(3):1851-7 , 2005
Shao, H , HS. Shi, HJ. Kaplan, D. Sun. Chronic recurrent autoimmune uveitis with progressive photoreceptor damage induced in rats by transfer of IRBP-specific T cells. J. Neuroimmunol, 163(1-2):102-9 , 2005
Shao , H , YX Fu, T Liao, Y Peng , LP Chen, HJ. Kaplan, D Sun. Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells. Invest Ophthalmol Vis Sci. 46:596-603 , 200 5
Shao , H. , SL. Sun, HJ. Kaplan, D. Sun: Characterization of rat CD8 + uveitogenic T cells specific for IRBP1177-1191. J Immuno l. , 173: 2849-2854, 2004
Shao, H ., Z. Huang, HJ. Kaplan, D. Sun. Adoptive transfer of Myelin / Oligodendrocyte Glycoprotein (MOG)-specific T Cells induced severe Optic Neuritis in C57Bl/6 mouse. Invest Ophthalmol Vis Sci. 45(11):4060-5, 2004
Education
Shanghai Medical University, School of Medicine, Shanghai, China, M.D., 1982
Shanghai Medical University, Graduate School, Shanghai, China, M.S., 1985 Free
University at Berlin, Germany, Ph.D. Immunology, 1990
Professional Societies and Affiliations
American Association of Immunologists, Association for Research in Vision and Ophthalmology, FAFSEB